Muthiah Manoharan Selected Research

Neoplasms (Cancer)

1/2021	Centyrin ligands for extrahepatic delivery of siRNA.
1/2016	A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo.
7/2012	An orthotopic bladder tumor model and the evaluation of intravesical saRNA treatment.
6/2012	Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.
3/2012	Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression.
1/2005	RNA interference in vivo: toward synthetic small inhibitory RNA-based therapeutics.

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Muthiah Manoharan Research Topics

Disease

6	Neoplasms (Cancer) 01/2021 - 01/2005
3	Hypercholesterolemia 01/2022 - 08/2008
2	Amyloidosis 01/2019 - 06/2016
2	Urinary Bladder Neoplasms (Bladder Cancer) 10/2012 - 07/2012
2	Inflammation (Inflammations) 01/2012 - 01/2009
1	Alzheimer Disease (Alzheimer's Disease) 10/2022
1	Primary Hyperoxaluria (Oxaluria, Primary) 01/2022
1	Colorectal Neoplasms (Colorectal Cancer) 01/2021
1	Cardiovascular Diseases (Cardiovascular Disease) 09/2016
1	Fatty Liver 09/2016
1	Atherosclerotic Plaque (Atheroma) 09/2016
1	Prostatic Neoplasms (Prostate Cancer) 01/2016
1	Hepatic Porphyrias (Hepatic Porphyria) 11/2015
1	Acute Intermittent Porphyria (Porphyria, Acute) 11/2015
1	Hemorrhage 05/2015
1	Hemophilia A (Haemophilia) 05/2015
1	Nervous System Diseases (Neurological Disorders) 12/2013
1	Chemical Burns (Chemical Burn) 07/2012
1	Rheumatoid Arthritis 01/2012
1	Disease Progression 01/2012
1	Melanoma (Melanoma, Malignant) 08/2011
1	Carcinoma (Carcinomatosis) 06/2011
1	Infections 01/2009
1	Kaposi Sarcoma (Kaposi's Sarcoma) 12/2007
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 10/2004
1	Carcinogenesis 05/2002

Drug/Important Bio-Agent (IBA)

8	Small Interfering RNA (siRNA)IBA 10/2022 - 01/2005
4	Lipid NanoparticlesIBA 01/2016 - 07/2012
4	RNA (Ribonucleic Acid)IBA 10/2012 - 06/2011
3	Proteins (Proteins, Gene)FDA Link 10/2022 - 12/2013
3	LigandsIBA 01/2022 - 06/2012
2	Amyloid (Amyloid Fibrils)IBA 10/2022 - 06/2016
2	LipidsIBA 01/2016 - 01/2009
2	CholesterolIBA 12/2010 - 01/2009
1	AcetylgalactosamineIBA 01/2022
1	givosiranIBA 01/2022
1	Antisense OligonucleotidesIBA 01/2022
1	OligonucleotidesIBA 01/2022
1	ALN-PCSIBA 01/2022
1	Acute Hepatic PorphyriaIBA 01/2022
1	lumasiranIBA 01/2022
1	Epithelial Cell Adhesion MoleculeIBA 01/2021
1	beta CateninIBA 01/2021
1	high density lipoprotein binding proteinIBA 09/2016
1	oxidized low density lipoproteinIBA 09/2016
1	Apolipoproteins B (ApoB)IBA 09/2016
1	LDL Lipoproteins (beta Lipoproteins)IBA 09/2016
1	Prealbumin (Transthyretin)IBA 06/2016
1	Androgen Receptors (Androgen Receptor)IBA 01/2016
1	Urea (Carbamide)FDA LinkGeneric 01/2016
1	Prostate-Specific Antigen (Semenogelase)IBA 01/2016
1	AntigensIBA 01/2016
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2016
1	Cell-Free Nucleic AcidsIBA 11/2015
1	Heme (Haem)IBA 11/2015
1	Factor VIII (Coagulation Factor VIII)IBA 05/2015
1	Factor IX (Coagulation Factor IX)FDA LinkGeneric 05/2015
1	AntithrombinsIBA 05/2015
1	Thrombin FDA Link 05/2015
1	AntibodiesIBA 05/2015
1	SolutionsIBA 07/2012
1	GlycosaminoglycansIBA 07/2012
1	Silver NitrateIBA 07/2012
1	DNA (Deoxyribonucleic Acid)IBA 06/2012
1	Peptides (Polypeptides)IBA 06/2012
1	Folic Acid (Vitamin M)FDA LinkGeneric 06/2012
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2012
1	LuciferasesIBA 08/2011
1	mahuang-tangIBA 06/2011
1	Tumor Viral Antigens (Large T Antigen)IBA 06/2011
1	Anti-Infective Agents (Microbicides)IBA 01/2009
1	InterferonsIBA 01/2009
1	MicroRNAs (MicroRNA)IBA 12/2007
1	Indicators and Reagents (Reagents)IBA 10/2004
1	DystrophinIBA 10/2004
1	XenobioticsIBA 05/2002
1	Protein Isoforms (Isoforms)IBA 05/2002

Therapy/Procedure

5	Therapeutics 01/2022 - 01/2012
4	RNAi Therapeutics 01/2021 - 08/2008
1	Intravenous Injections 01/2016
1	Intravesical Administration 10/2012
1	Catheters 07/2012